ViraSafe™ Universal Lentiviral Expression System, Pantropic

Blue Ice

Significantly reduced homology compared to other 3rd generation expression systems for added safety, without loss of titer
Complete Expression System contains packaging plasmids and expression vector
Cloning capacity of expression vector = 9.4 kb
Resulting VSVG-pseudotyped virus can infect virtually all cells regardless of species of origin

Viral Expression

Lentivirus based on HIV-1 provides a powerful means for gene expression because it can infect both dividing and non-dividing cells. Other 3rd generation lentiviral packaging systems provide a reduced risk of replication-competent virus, but a small risk remains. Our ViraSafe™ Lentivirus Expression Complete Systems provide a safer method even compared to other 3rd generation expression systems. Overlap with native HIV genes has been reduced much further, thereby substantially reducing the chance of generating replication-competent virus. The system has been engineered so that lentiviral titers remain at the levels of third generation systems. The Pantropic Expression Systems assemble VSVG-pseudotyped lentiviruses which can easily infect virtually any cells regardless of their species of origin.