Rat FLRT2 ELISA Kit PicoKine®

PicoKine® ELISA Kits

Rat FLRT2 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Flrt2 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene. It is mapped to 6q31. This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants.

Dilution ratio of 1:1, concentration in serum and plasma is around 40 pg/ml.

There is no detectable cross-reactivity with other relevant proteins.

A monoclonal antibody from mouse|a biotinylated detection polyclonal antibody from goat

heparin or EDTA

Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of c

Detected in brain.