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Human uPA / PLAU / URK ELISA Kit PicoKine®

Human uPA / PLAU / URK ELISA Kit PicoKine®

ArtNr	BOS-EK0535
Hersteller	Boster
Menge	96 wells/kit, with removable strips.
Kategorie	Oncology Food Safety Proteins ELISA Cardiovascular Research Atherosclerosis ELISA & Immunoassays ELISA Kits Immunoassay By Organ Breast Cancer
Typ	Elisa-Kit
Applikationen	ELISA
Specific against	Human
Sensitivity	<5 pg/ml
ECLASS 10.1	32160605
ECLASS 11.0	32160605
UNSPSC	41116126
Alias	Urokinase-type plasminogen activator;U-plasminogen activator;uPA;3.4.21.73;Urokinase-type plasminogen activator long chain A;Urokinase-type plasminogen activator short chain A;Urokinase-type plasminogen activator chain B;PLAU;
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Manufacturers Product Category	PicoKine® ELISA Kits
Short Description	Human uPA / PLAU / URK ELISA Kit PicoKine® (96 Tests). Quantitate Human PLAU in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 5pg/ml.
Description	Human uPA / PLAU / URK ELISA Kit PicoKine® (96 Tests). Quantitate Human PLAU in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 5pg/ml.
Background	Plasminogen activator, urokinase (PLAU, uPA) converts plasminogen to plasmin. Plasmin is involved in processing of amyloid precursor protein and degrades secreted and aggregated amyloid-beta, a hallmark of Alzheimer disease (AD). Urokinase has a molecular mass of about 54 kD and is composed of 2 disulfide-linked chains, A and B, of molecular masses 18 kD and 33 kD, respectively. It localized on 10q24. uPA facilitates cell migration by localizing proteolisys on the cell surface and by inducing intracellular signalling pathways. In human vascular smooth muscle cell (VSMC), uPA stimulates migration via the uPA receptor (uPAR) signalling complex containing TYK2 and phosphatidylinositol 3-kinase (PI3-K).
Gene Name	PLAU
Application Details	For serum, dilution ratio is 1:1 and concentration is 500-1700 pg/ml. For plasma, dilution ratio is 1:1 and concentration is 1000-2000 pg/ml.
Immunogen	Expression system for standard: NS0; Immunogen sequence: M1-L431
Cross-reactivity	There is no detectable cross-reactivity with other relevant proteins.
Sample Type	cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).
Capture antibody\|Detection antibody	monoclonal antibody from mouse\|polyclonal antibody from goat
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant	heparin or EDTA
Gene Full Name	Urokinase-type plasminogen activator
Molecular Weight	48507 MW
Protein Function	Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Subcellular Localization	Secreted.
Tissue Specificity	Expressed in the prostate gland and prostate cancers..
Protein Name	Urokinase-type plasminogen activator
Sequence Similarities	Belongs to the peptidase S1 family.

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