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Human PLGF/PGF ELISA Kit PicoKine®

Human PLGF/PGF ELISA Kit PicoKine®

ArtNr	BOS-EK0490
Hersteller	Boster
Menge	96 wells/kit, with removable strips.
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Neural Development By Cell Type Carcinoma Cell Biology Cell Culture Cytokines Adenocarcinoma ELISA ELISA & Immunoassays ELISA Kits Immunoassay By Organ Bladder Cancer Colorectal Cancer
Typ	Elisa-Kit
Applikationen	ELISA
Specific against	Human
Sensitivity	<1 pg/ml
ECLASS 10.1	32160605
ECLASS 11.0	32160605
UNSPSC	41116126
Alias	Placenta growth factor;PlGF;PGF;PGFL, PLGF;
Lieferbar
Manufacturers Product Category	PicoKine® ELISA Kits
Manufacturers Research Category	Cancer, Cancer Metabolism, Growth Factors/Hormones, Metabolism, Metabolism Processes, Pathways and Processes, Response To Hypoxia, Signal Transduction
Short Description	Human PLGF ELISA Kit PicoKine® (96 Tests). Quantitate Human PGF in cell culture supernatants, serum, plasma (heparin, EDTA, citrate) and urine. Sensitivity: 1pg/ml.
Description	Human PLGF ELISA Kit PicoKine® (96 Tests). Quantitate Human PGF in cell culture supernatants, serum, plasma (heparin, EDTA, citrate) and urine. Sensitivity: 1pg/ml.
Background	The protein, also called PGF, is 149 amino acids long and shares 53% identity with the platelet-derived growth factor-like region of human VPF. And the N-glycosylated PLGF protein is secreted into the medium and that it functions as a dimer1. The PLGF gene is mapped to 14q24-q31. There are 3 isoforms of PGF, designated PGF1, PGF2, and PGF3. Only PGF2 is able to bind heparin. Additionally, PGF regulates inter- and intramolecular cross-talk between the VEGF receptor tyrosine kinases FLT1 and FLK12. It also can stimulate angiogenesis and collateral growth in ischemic heart and limb with at least a comparable efficiency to VEGF3.
Gene Name	PGF
Application Details	Dilution ratio of 1:1, concentration in serum and plasma is 0-31 pg/ml.
Immunogen	Expression system for standard: E.coli; Immunogen sequence: A21-R149
Cross-reactivity	There is no detectable cross-reactivity with other relevant proteins.
Sample Type	cell culture supernatants, serum, plasma (heparin, EDTA, citrate) and urine.
Capture antibody\|Detection antibody	monoclonal antibody from mouse\|polyclonal antibody from goat
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant	heparin, EDTA or citrate
Gene Full Name	Placenta growth factor
Molecular Weight	24789 MW
Protein Function	Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth..
Subcellular Localization	Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
Tissue Specificity	While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
Protein Name	Placenta growth factor

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