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Human Angiogenin/ANG ELISA Kit PicoKine®

Human Angiogenin/ANG ELISA Kit PicoKine®

ArtNr	BOS-EK0305
Hersteller	Boster
Menge	96 wells/kit, with removable strips.
Kategorie	Oncology Neuroscience Neural Signaling By Cell Type ELISA ELISA & Immunoassays ELISA Kits Immunoassay
Typ	Elisa-Kit
Applikationen	ELISA
Specific against	Human
Sensitivity	<12 pg/ml
ECLASS 10.1	32160605
ECLASS 11.0	32160605
UNSPSC	41116126
Alias	Angiogenin;3.1.27.-;Ribonuclease 5;RNase 5;ANG;RNASE5;
Lieferbar
Manufacturers Product Category	PicoKine® ELISA Kits
Manufacturers Research Category	RNA Processing, Signal Transduction, Translation
Short Description	Human Angiogenin/ANG ELISA Kit PicoKine® (96 Tests). Quantitate Human ANG in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 12pg/ml.
Description	Human Angiogenin/ANG ELISA Kit PicoKine® (96 Tests). Quantitate Human ANG in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 12pg/ml.
Background	Angiogenin (Ang) also known as ribonuclease 5 is a protein that in humans is encoded by the ANG gene. Angiogenin is a potent stimulator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Hooper et al. (2003) reviewed the evidence that angiogenins are involved in host defense and noted that inflammation provokes upregulated ANG mRNA expression in liver and an increase in detectable ANG protein in serum. Weremowicz et al. (1989, 1990) assigned the human angiogenin gene to chromosome 14q11.
Gene Name	ANG
Application Details	Dilution ratio of 1:200, concentration in serum and plasma is 156-524 ng/ml.
Immunogen	Expression system for standard: E.coli; Immunogen sequence: Q25-P147
Cross-reactivity	There is no detectable cross-reactivity with other relevant proteins.
Sample Type	cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).
Capture antibody\|Detection antibody	monoclonal antibody from mouse\|polyclonal antibody from goat
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant	heparin or EDTA
Gene Full Name	Angiogenin
Molecular Weight	16550 MW
Protein Function	Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo..
Subcellular Localization	Nucleus. Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA.
Tissue Specificity	Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons..
Protein Name	Angiogenin
Sequence Similarities	Belongs to the pancreatic ribonuclease family.

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