Anti-Thymidylate Synthase (5-FU Resistance Marker) TYMS Monoclonal Antibody

Monoclonal Antibodies, Primary Antibodies

Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Monoclonal

TYMS

This monoclonal antibody recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5, 10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Purified antibody with BSA and azide at 200ug/ml

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.

Boster Bio Anti-Thymidylate Synthase (5-FU Resistance Marker) TYMS Monoclonal Antibody (Catalog # M04320). Tested in Flow Cytometry, IF, IHC applications. This antibody reacts with Human.