ArtNr |
BOS-M02423-1 |
Hersteller |
Boster
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Liquid |
Applikationen |
WB, IHC |
Clon |
RM356 |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
BAG family molecular chaperone regulator 1;BAG-1;Bcl-2-associated athanogene 1;BAG1;HAP; |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies, Monoclonal Antibodies |
Manufacturers Research Category |
Apoptosis, Apoptotic Markers, Atherosclerosis, Cancer, Cardiovascular, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes |
Short Description |
Boster Bio Anti-BAG-1 Rabbit Monoclonal Antibody, Clone#RM356 (Catalog # M02423-1). Tested in IHC, WB applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-BAG-1 Rabbit Monoclonal Antibody, Clone#RM356 (Catalog # M02423-1). Tested in IHC, WB applications. This antibody reacts with Human. |
Gene Name |
BAG1 |
Clonality |
Monoclonal |
Concentration |
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
50% Glycerol/PBS with 1% BSA and 0.09% sodium azide |
Application Details |
Immunohistochemistry (IHC): 1:500-1:1000 dilution
WB: 1:1000-1:2000 dilution. |
Immunogen |
A peptide corresponding to human BAG-1 (Bcl-2-associated athanogene 1) |
Cross-reactivity |
This antibody reacts to total human BAG-1 protein, including long (BAG-1L), medium (BAG-1M) and short (BAG-1S) isoforms |
Purification |
Protein A affinity purified from an animal origin-free culture supernatant |
Storage |
Store at -20°C for one year. Avoid repeated freeze-thaw cycles. |
Gene Full Name |
BAG family molecular chaperone regulator 1 |
Molecular Weight |
38779 MW |
Protein Function |
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631). |
Subcellular Localization |
Isoform 1: Nucleus. Cytoplasm. Isoform 1 localizes predominantly to the nucleus. |
Tissue Specificity |
Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level). |
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