ArtNr |
BOS-M01532 |
Hersteller |
Boster
|
Menge |
100 ul |
Kategorie |
|
Typ |
Antibody Monoclonal |
Format |
Liquid |
Applikationen |
WB, FC, IF, IP, IHC, ICC |
Clon |
GFE-13 |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
Macrophage-stimulating protein receptor;MSP receptor;2.7.10.1;CDw136;Protein-tyrosine kinase 8;p185-Ron;CD136;Macrophage-stimulating protein receptor alpha chain;Macrophage-stimulating protein receptor beta chain;MST1R;PTK8, RON; |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies, Rabbit Monoclonal Antibodies |
Manufacturers Research Category |
Cell Biology, Cell Cycle, Kinases/Phosphatases, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Tyrosine Kinases |
Short Description |
Boster Bio Anti-RON Rabbit Monoclonal Antibody catalog # M01532. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-RON Rabbit Monoclonal Antibody catalog # M01532. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human. |
Gene Name |
MST1R |
Application Details |
WB 1:1000-1:2000 IHC 1:50-1:200 ICC/IF 1:50-1:200 IP 1:30 FC 1:30 |
Clonality |
Monoclonal |
Concentration |
Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
Immunogen |
A synthesized peptide derived from human RON |
Purification |
Affinity-chromatography |
Storage |
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Gene Full Name |
Macrophage-stimulating protein receptor |
Molecular Weight |
152271 MW |
Protein Function |
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.. |
Subcellular Localization |
Membrane; Single-pass type I membrane protein. |
Tissue Specificity |
Expressed in colon, skin, lung and bone marrow.. |
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