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Anti-MBD1 Antibody

Anti-MBD1 Antibody

Hersteller	Boster
Kategorie	Antibodies Flow Cytometry Western Blot Primary Antibodies
Typ	Antibody
Specific against	Human, Mouse
Format	Liquid
Applikationen	WB, ELISA, CHIP
Menge	50ug/72ul
Host	Rabbit
ArtNr	BOS-CI1058
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Alias	Methyl-CpG-binding domain protein 1;CXXC-type zinc finger protein 3;Methyl-CpG-binding protein MBD1;Protein containing methyl-CpG-binding domain 1;MBD1;CXXC3, PCM1;
Manufacturers Product Category	Primary Antibodies
Manufacturers Research Category	Epigenetics and Nuclear Signaling
Short Description	Boster Bio Anti-MBD1 Antibody (Catalog# CI1058). Tested in ChIP, ELISA, WB applications. This antibody reacts with Human, Mouse.
Description	Boster Bio Anti-MBD1 Antibody (Catalog# CI1058). Tested in ChIP, ELISA, WB applications. This antibody reacts with Human, Mouse.
Background	MBD1 is a transcriptional repressor that specifically binds to methylated CpG dinucleotides in promoter sequences. MBD1 acts by recruiting a variety of histone deacetylases (HDAC’s) and chromatin remodelling factors. MBD1-dependent transcriptional repression is mediated by ATF7IP through the recruitment of factors such as the histone methyltransferase SETDB1. MBD1 probably forms a complex with SETDB1 and ATF7IP which couples DNA methylation to H3K9 trimethylation and represses transcription.
Gene Name	MBD1
Clonality	Polyclonal
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Contents	Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Application Details	User needs to optimize the dilution ratio for this antibody.
Immunogen	This antibody is raised in rabbit against human MBD1 (Methyl-CpG-binding domain protein 1), using a KLH-conjugated synthetic peptide containing a sequence from the N-terminal part of the protein.
Purification	Affinity purified
Storage	Store at -20°C. For long-term storage, store at -80°C. Avoid multiple freeze-thaw cycles.
Gene Full Name	Methyl-CpG-binding domain protein 1
Molecular Weight	66607 MW
Protein Function	Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Subcellular Localization	Nucleus. Nucleus matrix. Nucleus speckle. Chromosome. Colocalizes with the Ten-1 ICD form of TENM1 in foci associated with the nuclear matrix (By similarity). Nuclear, in a punctate pattern. Associated with euchromatic regions of the chromosomes, with pericentromeric regions on chromosome 1 and with telomeric regions from several chromosomes.
Tissue Specificity	Widely expressed.
Protein Name	Methyl-CpG-binding domain protein 1
Sequence Similarities	Contains 3 CXXC-type zinc fingers.

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Menge: 50ug/72ul

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Lieferung vsl. bis 02.08.2024

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