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Anti-EIF2 Alpha Eif2s1 Antibody Europäischer Partner

ArtNr BOS-A04387
Hersteller Boster
Menge 200ug
Kategorie
Typ Antibody
Format Liquid
Applikationen WB, IHC
Specific against Human, Mouse, Rat
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Eukaryotic translation initiation factor 2 subunit 1;Eukaryotic translation initiation factor 2 subunit alpha;eIF-2-alpha;eIF-2A;eIF-2alpha;Eif2s1;Eif2a;
Lieferbar
Manufacturers Product Category
Primary Antibodies
Manufacturers Research Category
DNA/RNA, Epigenetics and Nuclear Signaling, RNA Processing, Translation
Short Description
Boster Bio Anti-EIF2 Alpha Eif2s1 Antibody catalog # A04387. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Description
Boster Bio Anti-EIF2 Alpha Eif2s1 Antibody catalog # A04387. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Background
EIF2S1 (Eukaryotic Translation Initiation Factor 2, Subunit 1), also called EIF2-alpha, is a protein that in humans is encoded by the EIF2S1 gene. Hartz (2010) mapped the EIF2S1 gene to chromosome 14q23.3 based on an alignment of the EIF2S1 sequence with the genomic sequence (GRCh37). Ernst et al. (1987) stated that protein synthesis is inhibited due to phosphorylation of Eif2-alpha in hemin-deprived rabbit reticulocyte lysates. HeLa cells subjected to heat shock, serum deprivation, or interferon treatment followed by virus infection also show a correlation between EIF2-alpha phosphorylation and translational repression. Jacob et al. (1989) found that the alpha-Pal transcription factor bound to 2 palindromic sites within the EIF2-alpha promoter and was essential for transcription of the EIF2-alpha gene.
Gene Name
EIF2S1
Clonality
Polyclonal
Concentration
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Contents
Each vial contains 0.09% sodium azide and 50% glycerol.
Application Details
WB, 1μg/ml, ECL, Human, Mouse, Rat
Immunogen
Synthetic peptide corresponding to a portion of rat eIF2-alpha.
Purification
Immunoaffinity purified.
Gene Full Name
Eukaryotic translation initiation factor 2 subunit 1
Molecular Weight
36108 MW
Protein Function
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Subcellular Localization
Cytoplasmic granule. The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity)..
Protein Name
Eukaryotic translation initiation factor 2 subunit 1 (Eif2s1)

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 200ug
Lieferbar: In stock
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