ArtNr |
BOS-A03722 |
Hersteller |
Boster
|
Menge |
100ug |
Kategorie |
|
Typ |
Antibody |
Format |
Liquid |
Applikationen |
WB, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 5.1 |
32160702 |
ECLASS 6.1 |
32160702 |
ECLASS 8.0 |
32160702 |
ECLASS 9.0 |
32160702 |
ECLASS 10.0.1 |
32160702 |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
FKBP8, FKBP 8, FKBP-38, 38 kDa FK 506 binding protein homolog, 38kDa, FK506 binding protein 8, FKBP 38 |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies |
Short Description |
Boster Bio Anti-FKBP8 Antibody (Catalog # A03722). Tested in ELISA, WB applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-FKBP8 Antibody (Catalog # A03722). Tested in ELISA, WB applications. This antibody reacts with Human. |
Background |
FKBP8 (also known as FK506-binding protein 38) is a member of the immunophilin family that has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP8 by RNAi or transfection of a mutant FKBP8 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP8 may play a role in the regulation of apoptosis. Anti-FKBP8 Antibody is useful for researchers interested in HIV, Cancer, and Metabolism of protein research. |
Gene Name |
FKBP8 |
Clonality |
Polyclonal |
Concentration |
2.3 mg/mL by UV absorbance at 280 nm |
Contents |
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide |
Application Details |
ELISA: 1:25, 000 WB: 1:500 - 1:2, 000 |
Application Notes |
This protein A purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 64 kDa in size corresponding to FKBP8 by western blotting in the appropriate cell lysate or extract. |
Immunogen |
This protein A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human FKBP8 protein. |
Purification |
This product was protein A purified from monospecific antiserum by immunoaffinity chromatography using protein A coupled to agarose beads. This antibody is specific for human FKBP8 protein. A BLAST analysis was used to suggest partial cross-reactivity with FKBP8 from mouse and rat sources based on ~93% homology with the immunizing sequence. Cross-reactivity with FKBP8 from other sources has not been determined. |
Storage |
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening. |
Format Information |
Liquid (sterile filtered) |
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