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Anti-AES Antibody Picoband™

Anti-AES Antibody Picoband™

ArtNr	BOS-A01757-1
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Metabolism Diabetes Glucose Homeostasis Antibodies Western Blot ELISA Primary Antibodies
Typ	Antibody Primary
Format	Lyophilized
Applikationen	WB, FC, IF, IHC, ICC, ELISA
Specific against	Human
Host	Rabbit
Isotype	IgG
Citations	1. Hartley, D. A., Preiss, A., Artavanis-Tsakonas, S. A deduced gene product from the Drosophila neurogenic locus, enhancer of split, shows homology to mammalian G-protein beta subunit. Cell 55: 785-795, 1988.<br/>2. Hou, E. W., Li, S.-L. Genomic organization and chromosome localization to band 19p13.3 of the human AES gene: gene product exhibits strong similarity to the N-terminal domain of Drosophila enhancer of split Groucho protein. DNA Cell Biol. 17: 911-913, 1998. <br/>3. Miyasaka, H., Choudhury, B. K., Hou, E. W., Li, S. S.-L.Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. Europ. J. Biochem. 216: 343-352, 1993.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Amino-terminal enhancer of split; Amino enhancer of split; Gp130-associated protein GAM; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG; AES; GRG; GRG5
Lieferbar
Specificity	No cross reactivity with other proteins.
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Short Description	Boster Bio Anti-AES Antibody Picoband™ catalog # A01757-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-AES Antibody Picoband™ catalog # A01757-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human.
Background	The AES gene is mapped to 19p13.3. The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene.
Gene Name	AES
Application Details	Western blot, 0.1-0.5μg/ml, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat Immunocytochemistry/Immunofluorescence, 2μg/ml, Human Flow Cytometry, 1-3μg/1x10⁶ cells, Human Direct ELISA, 0.1-0.5μg/ml, Human
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.
Immunogen	E. coli-derived human AES recombinant protein (Position: Y69-L138).
Cross-reactivity	No cross-reactivity with other proteins.
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	amino-terminal enhancer of split
Molecular Weight	22 kDa
Protein Function	Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
Subcellular Localization	Nucleus.
Tissue Specificity	Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.

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Menge: 100 ug/vial

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Lieferung vsl. bis 13.09.2024

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