ArtNr |
BOS-A01617-Dyl488 |
Hersteller |
Boster
|
Menge |
100 ug/vial |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Liquid |
Applikationen |
FC |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
Konjugat/Tag |
DyLight 488 |
Citations |
1. Vasioukhin, V., Bauer, C., Degenstein, L., Wise, B., Fuchs, E. Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell 104: 605-617, 2001.<br/>2. Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R (November 1991). "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue". Proc Natl Acad Sci U S A 88 (20): 9156–60.<br/>3. "Entrez Gene: CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa"<br/> |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Catenin alpha-1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13; CTNNA1 |
Lieferbar |
|
Specificity |
No cross reactivity with other proteins. |
Manufacturers Product Category |
Primary Antibodies, Rabbit Polyclonal Antibodies |
Manufacturers Research Category |
Actin, etc., Cadherins, Cancer, Cell Adhesion, Cytoplasmic, Cytoskeleton, Cytoskeleton/ECM, Invasion/Microenvironment, Microfilaments, Signal Transduction, Signaling Pathways, Stem Cells |
Short Description |
Boster Bio Anti-Human CTNNA1 DyLight® 488 conjugated Antibody catalog # A01617-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-Human CTNNA1 DyLight® 488 conjugated Antibody catalog # A01617-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human. |
Background |
CTNNA1, also known as Catenin alpha-1 or Catenin (cadherin-associated protein), alpha 1, is a protein that in humans is encoded by the CTNNA1 gene. It is mapped to 5q31.2. When surface epithelium CTNNA1 was ablated, hair follicle development was blocked and epidermal morphogenesis was dramatically affected, with defects in adherens junction formation, intercellular adhesion, and epithelial polarity. In vitro, CTNNA1 null keratinocytes were poorly contact inhibited and grew rapidly. These differences were not dependent upon intercellular adhesion and were in marked contrast to keratinocytes conditionally null for another essential intercellular adhesion protein, desmoplakin Knockout keratinocytes exhibited sustained activation of the Ras-MAPK cascade due to aberrations in growth factor responses. It is concluded that features of precancerous lesions often attributed to defects in cell cycle regulatory genes can be generated by compromising the function of CTNNA1. |
Gene Name |
CTNNA1 |
Application Details |
Flow Cytometry, 1-3μg/1x106 cells |
Clonality |
Polyclonal |
Concentration |
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3. |
Immunogen |
E.coli-derived human CTNNA1 recombinant protein (Position: D143-D292). Human CTNNA1 shares 98% amino acid (aa) sequence identity with mouse CTNNA1. |
Cross-reactivity |
No cross-reactivity with other proteins. |
Storage |
At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light. |
Gene Full Name |
catenin (cadherin-associated protein), alpha 1, 102kDa |
Protein Function |
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. |
Subcellular Localization |
Isoform 1: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Found at cell-cell boundaries and probably at cell-matrix boundaries. |
Tissue Specificity |
Expressed ubiquitously in normal tissues. |
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