Anti-MDM2 (Ab-166) Antibody

Primary Antibodies

Boster Bio Anti-MDM2 (Ab-166) Antibody (Catalog # A00054-1). Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat, Monkey.

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues



Haupt, Y. et al. (1997) Nature 387, 296-299.

Zhou, B. P. et al. (2001) Nat. Cell Biol. 3, 973-981.

Grossman, S. R. et al. (1998) Mol. Cell 2, 405-415.

Mayo, L.D. and Donner, D.B. (2001) Proc. Natl. Acad. Sci. USA 98, 11598-11603.

Polyclonal

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Peptide sequence around aa.164~168 (A-T-S-E-T) derived from Human MDM2.

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.