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Anti-GABA A Receptor beta 3/GABRB3 Antibody Picoband™

Anti-GABA A Receptor beta 3/GABRB3 Antibody Picoband™

ArtNr	BOS-PB9595
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Food Safety Histamines Neuroscience Molecular Targets for Neuroscience Neural Signaling Antibodies Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Gamma-aminobutyric acid receptor subunit beta-3;GABA (A) receptor subunit beta-3;GABRB3;
Lieferbar
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Short Description	Boster Bio Anti-GABA A Receptor beta 3/GABRB3 Antibody Picoband™ catalog # PB9595. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-GABA A Receptor beta 3/GABRB3 Antibody Picoband™ catalog # PB9595. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Background	This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. And this gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. It may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Gene Name	GABRB3
Application Details	Western blot, 0.1-0.5μg/ml, Mouse, Rat, Human
Application Notes	Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Predicted Reactivity	Hamster
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human GABRB3, different from the related mouse and rat sequences by five amino acids.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	Gamma-aminobutyric acid receptor subunit beta-3
Molecular Weight	54116 MW
Protein Function	Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel..
Subcellular Localization	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein Name	Gamma-aminobutyric acid receptor subunit beta-3
Sequence Similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily.

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