Anti-IP3 receptor/ITPR1 Antibody

Inositol 1, 4, 5-trisphosphate receptor type 1, also known as IP3R or IP3R1, is a protein that in humans is encoded by the ITPR1 gene. It is mapped to 3p26.1. The product of the ITPR1 gene is predominantly enriched in cerebellar Purkinje cells but is also concentrated in neurons in the hippocampal CA1 region, caudate-putamen, and cerebral cortex. The ITPR1 gene encodes the inositol 1, 4, 5-triphosphate(IP3) receptor, an intracellular IP3-gated calcium channel that modulates intracellular calcium signaling. Upon stimulation by inositol 1, 4, 5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. This gene has been shown to interact with CA8, PRKG1, FKBP1A and so on.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Rabbit IgG polyclonal antibody for Inositol 1, 4, 5-trisphosphate receptor type 1(ITPR1) detection. Tested with WB, IHC-P in Human; Mouse; Rat.

ITPR1

313929 MW

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1, 4, 5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Belongs to the InsP3 receptor family.

Endoplasmic reticulum membrane; Multi-pass membrane protein.