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Anti-SMAD5 Antibody

Anti-SMAD5 Antibody

ArtNr	BOS-PA2115
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Oncology Neuroscience Targets for Rodent Neurosciences Antibodies Immunohistochemistry Western Blot Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB, IHC
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Mothers against decapentaplegic homolog 5;MAD homolog 5;Mothers against DPP homolog 5;JV5-1;SMAD family member 5;SMAD 5;Smad5;hSmad5;SMAD5;MADH5;
Similar products	MAD, DKFZp781C1895 antibody, DKFZp781O1323 antibody, Dwfc antibody, hSmad 5 antibody, hSmad5 antibody, JV5 1 antibody, JV5-1 antibody, MAD homolog 5 antibody, MAD mothers against decapentaplegic homolog 5 antibody, mothers against decapentaplegic homolog 5 antibody, MADH 5 antibody, MADH5 antibody, Mothers against decapentaplegic homolog 5 antibody, Mothers against DPP homolog 5 antibody, MusMLP antibody, SMA and MAD related protein 5 antibody, SMAD 5 antibody, SMAD family member 5 antibody, SMAD mothers against DPP homolog 5 antibody, Smad5 antibody, SMAD5_HUMAN antibody
Lieferbar
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	Cytoplasmic, Developmental Biology, Epigenetics and Nuclear Signaling, Nuclear Signaling, Nuclear Signaling Pathways, Organogenesis, Signal Transduction, Signaling Pathway, Stem Cells, TGF Beta
Short Description	Boster Bio Anti-SMAD5 Antibody catalog # PA2115. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-SMAD5 Antibody catalog # PA2115. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Background	Mother against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SAMD5 gene. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. The gene was assigned to human chromosome 5q31. Like many other TGFbeta family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). It may play a role in the pathway where TGFbeta is an inhibitor of hematopoietic progenitor cells.
Gene Name	SMAD5
Application Details	Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
Application Notes	WB: The detection limit for SMAD5 is approximately 1.5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
Predicted Reactivity	Hamster
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen	A synthetic peptide corresponding to a sequence in the middle region of human SMAD5, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	Mothers against decapentaplegic homolog 5
Molecular Weight	52258 MW
Protein Function	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).
Subcellular Localization	Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
Tissue Specificity	Ubiquitous.
Protein Name	Mothers against decapentaplegic homolog 5
Sequence Similarities	Belongs to the dwarfin/SMAD family.

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