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Anti-Smad Interacting Protein 1/ZEB2 Antibody

Anti-Smad Interacting Protein 1/ZEB2 Antibody

ArtNr	BOS-PA1959
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Antibodies Western Blot Primary Antibodies By Organ Bladder Cancer Testicular & Prostate Cancer
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB, IHC
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Zinc finger E-box-binding homeobox 2;Smad-interacting protein 1;SMADIP1;Zinc finger homeobox protein 1b;ZEB2;KIAA0569, SIP1, ZFHX1B, ZFX1B;HRIHFB2411;
Similar products	FLJ42816 antibody, HSPC082 antibody, KIAA0569 antibody, SIP 1 antibody, SIP1 antibody, Smad-interacting protein 1 antibody, SMADIP 1 antibody, SMADIP1 antibody, ZEB 2 antibody, Zeb2 antibody, ZEB2_HUMAN antibody, Zfhx1b antibody, ZFHX1B protein antibody, Zfx1b antibody, Zinc finger E box binding protein 2 antibody, Zinc finger E-box-binding homeobox 2 antibody, Zinc finger homeobox 1b antibody, zinc finger homeobox protein 1 antibody, Zinc finger homeobox protein 1b antibody
Lieferbar
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Lineage Markers, Lineage Specification, Neurogenesis, Neurology Process, Neuroscience, Oncoproteins, Oncoproteins/Suppressors, Stem Cells, Transcription, Transcription Factors
Short Description	Boster Bio Anti-Smad Interacting Protein 1/ZEB2 Antibody catalog # PA1959. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-Smad Interacting Protein 1/ZEB2 Antibody catalog # PA1959. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Background	ZEB2 (Zinc finger E-box-binding homeobox2), also known as SIP1or ZINC FINGER HOMEOBOX 1B (ZFHX1B), is a protein that in humans is encoded by the ZEB2 gene. The ZEB2 gene is a member of the ZEB1/Drosophila Zfh1 family of 2-handed zinc finger/homeodomain proteins and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs, the transducers of TGF-beta signaling, and interacts with the nucleosome remodeling and histone deacetylation (NURD) complex. By radiation hybrid analysis, Nagase et al. (1998) mapped the ZEB2 gene to chromosome 2. Wakamatsu et al. (2001) mapped the ZEB2 gene to chromosome 2q22. Vandewalle et al. (2005) showed that expression of mouse Sip1 in human epithelial cells caused a morphologic change from an epithelial to a mesenchymal phenotype. Expression of SNAI1 in epithelial cells triggers an epithelial-mesenchyme transition. Beltran et al. (2008) showed that synthesis of ZEB2 was upregulated following SNAI1 expression in human cell lines.
Gene Name	ZEB2
Application Details	Western blot, 0.1-0.5μg/ml, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Application Notes	WB: The detection limit for ZEB2 is approximately 0.5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
Predicted Reactivity	Hamster
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.01mg NaN3.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human ZEB2, identical to the related rat and mouse sequences.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	Zinc finger E-box-binding homeobox 2
Molecular Weight	136447 MW
Protein Function	Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E- cadherin..
Subcellular Localization	Nucleus.
Protein Name	Zinc finger E-box-binding homeobox 2
Sequence Similarities	Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

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