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Anti-Heat shock protein beta-2 HSPB2 Antibody

Anti-Heat shock protein beta-2 HSPB2 Antibody

ArtNr	BOS-PA1802
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Oncology Antibodies Immunohistochemistry Western Blot Immunocytochemistry Primary Antibodies By Organ Skin Cancer
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB, IHC, ICC
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Heat shock protein beta-2;HspB2;DMPK-binding protein;MKBP;HSPB2;
Similar products	HSP27 antibody, DMPK-binding protein antibody, Heat shock 27kD protein 2 antibody, Heat shock 27kDa protein 2 antibody, Heat shock protein beta-2 antibody, Heat-shock protein beta-2 antibody, Hs.78846 antibody, HspB2 antibody, HSPB2_HUMAN antibody, LOH11CR1K antibody, MGC133245 antibody, MKBP antibody
Lieferbar
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	Chaperones, Heat Shock Proteins, Protein Trafficking, Signal Transduction
Short Description	Boster Bio Anti-Heat shock protein beta-2 HSPB2 Antibody catalog # PA1802. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-Heat shock protein beta-2 HSPB2 Antibody catalog # PA1802. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
Background	Alpha-B-crystallin is a member of the alpha-crystallin/small heat-shock protein (HSP) family and under various neuropathologic conditions accumulates in reactive astrocytes and degenerating neurons. In the 5-prime flanking region of the CRYAB gene on 11q22-q23, where a constitutive DNaseI hypersensitive site is located, Iwaki et al. (1997) identified a gene transcribed in the opposite direction. Analysis of its mRNA structure by RT-PCR and 5-prime/3-prime RACE revealed that this gene is composed of 2 exons and encodes a new member of the alpha-crystallin/hsp family. They termed the gene HSPB2. Iwaki et al. (1997) also determined the complete genomic structure of the rat homolog of HSPB2. Southern blot analysis demonstrated that HSPB2is expressed preferentially in skeletal muscle and heart but not in the lens, while the neighboring CRYAB gene is highly expressed in all 3 tissues. The 2 related genes are arranged in a head-to-head manner with an intergenic sequence of less than 1 kb, raising a possibility of shared regulatory elements for their expression.
Gene Name	HSPB2
Application Details	Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat Immunohistochemistry (Frozen Section), 0.5-1μg/ml, Rat, Human, Mouse Immunocytochemistry , 0.5-1μg/ml, Human, Mouse, Rat
Application Notes	Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Predicted Reactivity	Hamster
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen	A synthetic peptide corresponding to a sequence in the middle region of human HSPB2, identical to the related rat and mouse sequences.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	Heat shock protein beta-2
Molecular Weight	20233 MW
Protein Function	May regulate the kinase DMPK..
Subcellular Localization	Cytoplasm. Nucleus. Localizes to nuclear foci.
Tissue Specificity	Expressed preferentially in skeletal muscle and heart but not in the lens.
Protein Name	Heat shock protein beta-2(HspB2)
Sequence Similarities	Belongs to the small heat shock protein (HSP20) family.

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