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Anti-XRCC1 Antibody

Anti-XRCC1 Antibody

ArtNr	BOS-PA1639
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Sarcoma Cell Biology Adenocarcinoma Cytoskeleton Immunohistochemistry Western Blot Immunocytochemistry Primary Antibodies By Organ Renal Cancer small GTPases Rab Subfamily
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB, IHC, ICC
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
Sensitivity	>5000 cells
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	DNA repair protein XRCC1;X-ray repair cross-complementing protein 1;XRCC1;
Similar products	complementing defective, X ray repair, DNA repair protein XRCC1 antibody, RCC antibody, X ray repair complementing defective repair in chinese hamster antibody, X ray repair complementing defective repair in chinese hamster cells 1 antibody, X ray Repair Complementing Defective Repair in Chinese Hamster Cells antibody, X ray repair cross complementing protein 1 antibody, repair in Chinese hamster antibody, X-ray repair cross-complementing protein 1 antibody, XRCC 1 antibody, Xrcc1 antibody, XRCC1_HUMAN antibody
Lieferbar
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	Cancer, Cancer Metabolism, DNA/RNA, DNA Damage & Repair, Epigenetics and Nuclear Signaling, Metabolic Signaling Pathways, Metabolism, Metabolism Processes, Nucleotide Metabolism, Pathways and Processes, Response To Hypoxia
Short Description	Boster Bio Anti-XRCC1 Antibody catalog # PA1639. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-XRCC1 Antibody catalog # PA1639. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
Background	XRCC1 (X-RAY REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 1) is a DNA repair protein which complexes with DNA ligase III. The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. The XRCC1 gene is mapped to 19q13.31. The XRCC1 interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. XRCC1 is phosphorylated in vivo and in vitro by CK2, and CK2 phosphorylation of XRCC1 on ser518, thr519, and thr523 largely determines aprataxin binding to XRCC1 through its FHA domain.
Gene Name	XRCC1
Application Details	Immunocytochemistry , 0.5-1μg/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat
Application Notes	Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
Predicted Reactivity	Hamster
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminus of human XRCC1, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	DNA repair protein XRCC1
Molecular Weight	69477 MW
Protein Function	Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
Subcellular Localization	Nucleus. Accumulates at sites of DNA damage.
Protein Name	DNA repair protein XRCC1
Sequence Similarities	Contains 2 BRCT domains.

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