ArtNr |
BOS-A00373-2 |
Hersteller |
Boster
|
Menge |
100 ug/vial |
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Lyophilized |
Applikationen |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, CD24, CD24, CD24A |
Lieferbar |
|
Background |
Signal transducer CD24, also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA), is a protein that in humans is encoded by the CD24 gene. This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. |
Contents |
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
Cross reactivity |
No cross reactivity with other proteins. |
Description |
Rabbit IgG polyclonal antibody for CD24 detection. Tested with WB in Human, Mouse, Rat. |
Gene full name |
CD24 molecule |
Gene name |
CD24 |
Immunogen |
A synthetic peptide corresponding to a sequence of human CD24 (SETTTGTSSNSSQSTSNTGLAPNPTNATTKAA). |
Protein function |
May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity). |
Recommended detection systems |
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot. |
Reconstitution |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Storage |
At -20℃ for one year. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for a longer time. Avoid repeated freezing and thawing. |
Subcellular localization |
Cell membrane; Lipid-anchor, GPI-anchor. |
Tissue specificity |
B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. |
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