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Anti-Fibroblast growth factor 2 FGF2 Antibody

Anti-Fibroblast growth factor 2 FGF2 Antibody

Hersteller	Boster
Kategorie	Oncology Neuroscience Neural Adhesion Molecules Antibodies By Cell Type Carcinoma Hematology Leukemia Myeloma Cell Biology Cell Culture Cytokines Immunohistochemistry Western Blot ELISA Primary Antibodies By Organ Bladder Cancer Hepatic Cancer
Typ	Antibody Polyclonal
Specific against	Human
Isotype	IgG
Format	Lyophilized
Applikationen	WB, FC, IF, ICC, ELISA
Menge	100 ug/vial
Host	Rabbit
ArtNr	BOS-RP1006
Targets	FGF13, FGF2
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Alias	Fibroblast growth factor 2;FGF-2;Basic fibroblast growth factor;bFGF;Heparin-binding growth factor 2;HBGF-2;FGF2;FGFB;
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	Angiogenesis, Cancer, Cardiovascular, Developmental Biology, Growth Factors, Growth Factors/Hormones, Invasion/Microenvironment, Neural Stem Cells, Neurogenesis, Neurology Process, Neuroscience, Organogenesis, Signal Transduction, Stem Cells
Short Description	Boster Bio Anti-Fibroblast growth factor 2 FGF2 Antibody catalog # RP1006. Tested in ELISA, Flow Cytometry(Intracellular), IF, ICC, WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-Fibroblast growth factor 2 FGF2 Antibody catalog # RP1006. Tested in ELISA, Flow Cytometry(Intracellular), IF, ICC, WB applications. This antibody reacts with Human.
Background	FGF2 has been implicated in a multitude of physiologic and pathologic processes, including limb development, angiogenesis, wound healing, and tumor growth. Human FGF2 shares 96% and 97% amino acid sequence homology with mouse and rat respectively. FGF2 belongs to the fibroblast growth factor (FGF) family. Fibroblast growth factors (FGFs) exhibit widespread mitogenic and neurotrophic activities. Nine members of the family are currently known, and FGF-1 and FGF-2 are present in relatively high levels in CNS. FGF-2 is expressed by at low levels in many tissues and cell types and reaches high concentrations in brain and pituitary.
Gene Name	FGF2
Application Details	Western blot, 0.1-0.5μg/ml, Human Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human Flow Cytometry(Intracellular), 1-3 μg/1x10⁶ cells, Human ELISA , 0.1-0.5μg/ml, Human, -
Application Notes	By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.
Immunogen	E.coli-derived human FGF2 recombinant protein (Position: P143-S288).
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	Fibroblast growth factor 2
Molecular Weight	30770 MW
Protein Function	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro..
Subcellular Localization	Secreted. Nucleus. Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.
Tissue Specificity	Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue..
Protein Name	Fibroblast growth factor 2
Sequence Similarities	Belongs to the heparin-binding growth factors family.

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