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Anti-VRL1/TRPV2 Antibody

Anti-VRL1/TRPV2 Antibody

ArtNr	BOS-PA1977
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB
Specific against	Human
Host	Rabbit
Isotype	IgG
Sensitivity	<10pg/ml
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Transient receptor potential cation channel subfamily V member 2;TrpV2;Osm-9-like TRP channel 2;OTRPC2;Vanilloid receptor-like protein 1;VRL-1;TRPV2;VRL;
Similar products	MGC12549 antibody, Osm 9 like TRP channel 2 antibody, osm-9-like TRP channel 2 antibody, OTRPC2 antibody, Sac2b antibody, Sac2b(gene name) antibody, Stretch activated channel 2B antibody, Stretch-activated channel 2B antibody, Transient receptor potential cation channel subfamily V member 2 antibody, TrpV2 antibody, TRPV2_HUMAN antibody, Vanilloid receptor like protein 1 antibody, Vanilloid receptor-like protein 1 antibody, VRL 1 antibody, VRL antibody, VRL-1 antibody, VRL1 antibody
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Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Short Description	Boster Bio Anti-VRL1/TRPV2 Antibody catalog # PA1977. Tested in WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-VRL1/TRPV2 Antibody catalog # PA1977. Tested in WB applications. This antibody reacts with Human.
Background	TRPV2 (Transient Receptor Potential Cation Channel Subfamily V Member 2), also known as VRL1, is a protein that, in humans, is encoded by the TRPV1 gene. The International Radiation Hybrid Mapping Consortium mapped the TRPV2 gene to chromosome 17. This gene encodes an ion channel that is activated by high temperatures above 52ËšC. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is though that in other tissues the channel may be activated by stimuli other than heat.
Gene Name	TRPV2
Application Details	Immunohistochemistry (Frozen Section), 0.5-1μg/ml, Human, - Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat Western blot, 0.1-0.5μg/ml, Human
Application Notes	WB: The detection limit for TRPV2 is approximately 0.5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminus of human VRL1.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	Transient receptor potential cation channel subfamily V member 2
Molecular Weight	85981 MW
Protein Function	Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH..
Subcellular Localization	Cell membrane ; Multi-pass membrane protein. Cytoplasm. Melanosome. Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV..
Protein Name	Transient receptor potential cation channel subfamily V member 2
Sequence Similarities	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.

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