ArtNr |
BOS-PA1550 |
Hersteller |
Boster
|
Menge |
100 ug/vial |
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Lyophilized |
Applikationen |
WB |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Interferon-induced guanylate-binding protein 1;GTP-binding protein 1;GBP-1;HuGBP-1;Guanine nucleotide-binding protein 1;GBP1; |
Similar products |
GBP 1 antibody, GBP-1 antibody, GBP1 antibody, GBP1_HUMAN antibody, GTP binding protein 1 antibody, GTP-binding protein 1 antibody, Guanine nucleotide binding protein 1 antibody, Guanine nucleotide-binding protein 1 antibody, Guanylate binding protein 1 antibody, Guanylate binding protein 1 interferon inducible 67kDa antibody, Guanylate binding protein 1 interferon inducible antibody, HuGBP 1 antibody, HuGBP-1 antibody, HuGBP1 antibody, Interferon induced guanylate binding protein 1 antibody, Interferon-induced guanylate-binding protein 1 antibody, OTTHUMP00000012352 antibody |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies, Rabbit Polyclonal Antibodies |
Manufacturers Research Category |
Signal Transduction |
Short Description |
Boster Bio Anti-Guanylate-binding protein 1 GBP1 Antibody catalog # PA1550. Tested in WB applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-Guanylate-binding protein 1 GBP1 Antibody catalog # PA1550. Tested in WB applications. This antibody reacts with Human. |
Background |
Interferons induce a large number of genes in their target cells, including those coding for guanylate-binding proteins (GBPs). GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. The 593-amino acid GBP1 protein shares 77% and 88% identity with GBP2 and GBP3, respectively. All GBPs, including GBP1, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T (L/V)RD sequence not found in other GTPases. The GBP1 gene to the GBP gene cluster on chromosome 1p22.2. It is located telomeric to GBP2 and centromeric to GBP3. High expression of GBP1, GBP2, and GBP3 are in endothelial cells after stimulation with IFNG, TNF, or IL1B. |
Gene Name |
GBP1 |
Application Details |
Western blot, 0.1-0.5μg/ml, Human |
Application Notes |
Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users. |
Clonality |
Polyclonal |
Concentration |
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml. |
Contents |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
Immunogen |
A synthetic peptide corresponding to a sequence at the C-terminus of human GBP1. |
Purification |
Immunogen affinity purified. |
Cross-reactivity |
No cross-reactivity with other proteins |
Storage |
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles. |
Reconstitution |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Gene Full Name |
Interferon-induced guanylate-binding protein 1 |
Molecular Weight |
67931 MW |
Protein Function |
Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.. |
Subcellular Localization |
Cytoplasm. Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side. Secreted. Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of interferon-gamma induction. Golgi membrane localization requires isoprenylation and the presence of another IFN-gamma-induced factor. |
Protein Name |
Guanylate-binding protein 1 |
Sequence Similarities |
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. |
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