ArtNr |
BOS-FC00344-100ug |
Hersteller |
Boster
|
Menge |
100ug |
Format |
Liquid |
Applikationen |
FC |
Clon |
OKT4 |
Specific against |
Human, Monkey, Rhesus macaque |
Host |
Mouse |
Isotype |
IgG2b Kappa |
Sensitivity |
5ul per sample |
Alias |
T-cell surface glycoprotein CD4;T-cell surface antigen T4/Leu-3;CD4;CD4; |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies, Monoclonal Antibodies |
Manufacturers Research Category |
Adaptive Immunity, Antiviral Signaling, Hematopoietic Progenitors, Immune System Diseases, Immunology, Lymphoid, Myeloid, Stem Cells, T Cells, T Lymphocytic Lineage |
Short Description |
Boster Bio Anti-human CD4 Monoclonal Antibody Unconjugated, Flow Validated (Catalog# FC00344). Tested in Flow Cytometry application(s). This antibody reacts with Human, Rhesus monkey, Cynomolgus monkey. |
Description |
Boster Bio Anti-human CD4 Monoclonal Antibody Unconjugated, Flow Validated (Catalog# FC00344). Tested in Flow Cytometry application(s). This antibody reacts with Human, Rhesus monkey, Cynomolgus monkey. |
Background |
CD stands for "cluster of differentiation"; the number that follows is arbitrarily assigned. In the full designation the cell type and nature and molecular weight of the antigen are given in brackets; for CD4, this is as follows: [T, gp55]. CD4 is present on a subset of T lymphocytes ("helper/inducer" T cells) and is also expressed at a lower level on monocytes, tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase. |
Gene Name |
CD4 |
Clonality |
Monoclonal |
Concentration |
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
PBS pH 7.2, 0.1% (w/v) BSA, 0.09% (w/v) sodium azide |
Application Details |
User needs to optimize the dilution ratio for this antibody. |
Immunogen |
Human peripheral blood T lymphocytes |
Purification |
Protein A purified |
Storage |
Store at 2-8°C. Avoid repeated freeze-thaw cycles. |
Gene Full Name |
T-cell surface glycoprotein CD4 |
Molecular Weight |
51111 MW |
Protein Function |
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. |
Subcellular Localization |
Cell membrane; Single-pass type I membrane protein. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. |
Protein Name |
T-cell surface glycoprotein CD4 |
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