ArtNr |
BS9829M-50 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
50 ul |
Quantity options |
100 ul
50 ul
|
Kategorie |
|
Typ |
Antibody Monoclonal |
Applikationen |
WB, FC, IHC, ICC |
Specific against |
Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus) |
Host |
Rabbit |
Konjugat/Tag |
Unconjugated |
Purity |
Protein A affinity purified |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
Keratin, type I cytoskeletal 17, Cytokeratin-17, Short name=CK-17, CK17, Keratin-17, Short name=K17, KRT17, Keratin17, Cytokeratin17, |
Lieferbar |
|
Application Notes |
WB: 1:500-1:1000 IHC/ICC/IF: 1:50-1:200 FC: 1:20-1:100 |
Background |
Cytokeratin 17 is a member of the Cytokeratin subfamily of intermediate filament proteins (IFPs). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 contains 432 amino acids and is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Cytokeratin 17 functions to regulate cell growth and size through its interactions with the adaptor protein 14-3-3-sigma to mediate protein synthesis. Mutations in the gene encoding for Cytokeratin 17 lead to depressed protein translation and smaller sized skin keratinocytes, corresponding to decreased Akt/mTOR signaling activity. Cytokeratin 17 may be a useful marker for cervical stem cell identification, squamous cell carcinoma of the larynx, respiratory syncytial virus and transitional cell carcinomas of the human urinary tract. |
Manufacturer - Product |
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Manufacturer - Specificity |
This antibody detects endogenous levels of Cytokeratin 17 and does not cross-react with related proteins. |
Molecular Weight |
~ 48 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Immunogen |
Recombinant antibody. |
Modification |
Unmodification |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.