FGF-13 (H184) polyclonal antibody

Q92913

Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. Fibroblast growth factor-13 (FGF-13), also known as FHF-2, is involved in nervous system development. The FGF13 gene, mapping by linkage to the q26 region of the human X chromosome, is a candidate gene for the Borjeson-Forssman-Lehmann syndrome (BFLS), an Xlinked mental retardation. It is highly expressed in brain and skeletal muscle.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

FGF-13 (H184) pAb detects endogenous levels of FGF-13 protein.

For research use only, not for use in diagnostic procedure.

Synthetic peptide, corresponding to amino acids 152-200 of Human FGF-13.