KIR2.3 (E285) polyclonal antibody

P48050

The KIR2 subunit family includes 2.1, 2.2, 2.3 and 2.4. Unlike G-protein coupled KIR3 subunits, KIR2.1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity. KIR2.1 is expressed in the superior and inferior collicula and the pontine region of the brain, where it moderates synaptic transmission, like many other potassium channels. In the placenta, KIR2.1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, KIR2.1 colocalizes with KIR5.1 in the proximal tubule. KIR2.1, 2.2 and 2.3 associate with the membrane-associated guanylate kinase synapse-associated protein 97 in the cerebellum and heart. Phosphorylation of KIR2.2 by protein kinase A inhibits the associates with SAP97. Arachidonic acid increases current amplitude in KIR2.3 activity but does not affect the activity of KIR2.1, 2.2 or 2.4.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

KIR2.3 (E285) pAb detects endogenous levels of KIR2.3 protein.

For research use only, not for use in diagnostic procedure.

Synthetic peptide, corresponding to amino acids 250-300 of Human KIR2.3.