ArtNr |
BS8134-50 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Zinc finger MYND domain-containing protein 11, Adenovirus 5 E1A-binding protein, Bone morphogenetic protein receptor-associated molecule 1, Protein BS69, ZMYND11, BRAM1, BS69 |
Similar products |
ZMYND11 |
Lieferbar |
|
Swiss-Prot |
Q15326 |
Application all |
WB: 1:500ca.1:2000 IHC: 1:50ca.1:200 |
Background |
The adenovirus E1A gene products are nuclear phosphoproteins with the ability to transactivate other adenovirus genes. BS69 specifically interacts with adenovirus 5 E1A and inhibits transactivation by the 289R E1A protein. BS69 interacts with the co-repressor N-CoR through an essential MYND domain in the carboxy terminus of N-CoR. BS69 also inhibits the transcriptional activity of c-Myb. During oncogenesis, this BS69/Myb regulatory circuit maybe be a target for disruption . Another ubiquitously expressed member of the Myb gene family, b-Myb, also interacts with BS69 and N-CoR to function as a transcriptional repressor. BRAM1, a splice variant of BS69, binds specifically to bone morphogenetic protein type IA receptor (BMPR-IA). BRAM1 localizes to the cytoplasm of mammalian cells, while BS69 localizes to the cell nucleus . Unlike BS69, BRAM1 is unable to repress transcription . |
Product |
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
ZMYND11 polyclonal antibody detects endogenous levels of ZMYND11 protein. |
WB |
WesternBlot (WB) analysis of ZMYND11 polyclonal antibody |
BiowMW |
ca. 71 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
Zinc finger MYND domain-containing protein 11, Adenovirus 5 E1A-binding protein, Bone morphogenetic protein receptor-associated molecule 1, Protein BS69, ZMYND11, BRAM1, BS69 |
Immunogen |
Recombinant full length Human ZMYND11. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.