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NOV polyclonal antibody

NOV polyclonal antibody

Hersteller	Bioworld Technology, Inc
Kategorie	Neuroscience Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot Endocrine Regulation of Lipid Metabolism Primary Antibodies
Typ	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applikationen	WB, IHC
Menge	50ul
Host	Rabbit
ArtNr	BS7748-50
Targets	INS ;;PLXNA1
eClass 6.1	32160702
eClass 9.0	32160702
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Alias	CCN family member 3, CCN3, IBP-9, IGF-binding protein 9, IGFBP-9, IGFBP9, Insulin-like growth factor-binding protein 9, Nephroblastoma overexpressed, Nephroblastoma overexpressed gene protein homolog, Nephroblastoma-overexpressed gene protein hom
Swiss-Prot	P48745
Application all	WB: 1:500ca.1:2000 IHC: 1:50ca.1:200
Background	The CCN (CTGF/Cyr61/NOV) family of genes presently consists of six distinct members, which encode proteins that participate in fundamental biological processes such as cell proliferation, adhesion, migration, differentiation, wound healing, angiogenesis and several pathologies including fibrosis and tumorigenesis. Whereas Cyr61 and CTGF act as positive regulators of cell growth, nov (nephroblastoma overexpressed, CCN3 or NOVH) provides the first example of a CCN protein with negative regulatory properties and the first example of aberrant expression being associated with tumor development. In animals and humans increased expression of nov is detected in tissues where calcium is a key regulator, such as the adrenal gland, central nervous system, bone and cartilage, heart muscle and kidney. The nov protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.
Product	1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	NOV pAb detects endogenous levels of NOV protein.
BiowMW	ca. 39 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	CCN family member 3, CCN3, IBP-9, IGF-binding protein 9, IGFBP-9, IGFBP9, Insulin-like growth factor-binding protein 9, Nephroblastoma overexpressed, Nephroblastoma overexpressed gene protein homolog, Nephroblastoma-overexpressed gene protein homolog, NOV, NOV_HUMAN, NovH, Protein NOV homolog,
Immunogen	Recombinant full length Human NOV.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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