INHA polyclonal antibody

P05111

Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises two subunits, Inhibin A and Inhibin B. Each subunit consists of the same alpha subunit, covalently linked to 1 of 2 distinct subunits, beta-alpha or beta-beta. Originally isolated from ovarian follicular fluid and characterized as a disulphide-linked dimeric glycoprotein, inhibin belongs to the transforming growth factor beta (TGFbeta) superfamily of growth and differentiation factors. TGFbeta proteins affect a range of tissues and systems beyond their role in reproduction. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal, bone marrow, placenta and, most notably, anterior pituitary. Inhibin alpha-subunit gene expression is down regulated in human prostate cancer, suggesting a tumor-suppressive role. The human Inhibin alpha gene maps to chromosome 2q33-q36.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

INHA pAb detects endogenous levels of INHA protein.

For research use only, not for use in diagnostic procedure.

Recombinant full length Human INHA.