ArtNr |
BS71277-50 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
CPK, PI3-K-C2A, PI3-K-C2(ALPHA), |
Lieferbar |
|
Buffer composition |
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Background |
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. |
Application info |
WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Swiss-Prot |
O00443 |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
PIK3C2A polyclonal antibody detects endogenous levels of PIK3C2A protein. |
BiowMW |
ca. 191 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
CPK, PI3-K-C2A, PI3-K-C2(ALPHA), |
Immunogen |
Recombinant protein of human PIK3C2A. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.