MASP1 (HC) polyclonal antibody

P48740

MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein, sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. MASP-3 is an alternatively spliced product from the MASP-1 gene. The heavy/A chains are identical between MASP-1 and MASP-3 but the light/B chains are entirely different. Activated MASPs subsequently cleave and activate downstream components of the complement pathway.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

MASP-1 (HC) pAb detects endogenous levels of Mannan-binding lectin serine protease 1 heavy chain.

ca. 47 kDa

Mannan-binding lectin serine protease 1, Complement factor MASP-3, Mannose-binding lectin-associated serine protease 1, MASP-1, Ra-reactive factor serine protease p100, RaRF, Serine protease 5, Mannan-binding lectin serine protease 1 heavy chain, MASP1, CRARF, CRARF1, PRSS5