Hersteller |
Bioworld Technology, Inc
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human, Mouse, Rat |
Applikationen |
WB |
Menge |
50ul |
Host |
Rabbit |
ArtNr |
BS6831-50 |
Targets |
HDAC7;;HDAC9;;MEF2A |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Alias |
Histone deacetylase 9, Short name=HD9, Histone deacetylase 7B, Short name=HD7, Short name=HD7b, Histone deacetylase-related protein, MEF2-interacting transcription repressor MITR, HDAC9, HDAC7, HDAC7B, HDRP, KIAA0744, MITR |
Swiss-Prot |
Q9UKV0 |
Application all |
WB: 1:500ca.1:2000 |
Background |
Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1-9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
HDAC9 pAb detects endogenous levels of HDAC9 protein. |
WB |
Western blot (WB) analysis of HDAC 9 pAb |
BiowMW |
ca. 111, 160 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
Histone deacetylase 9, Short name=HD9, Histone deacetylase 7B, Short name=HD7, Short name=HD7b, Histone deacetylase-related protein, MEF2-interacting transcription repressor MITR, HDAC9, HDAC7, HDAC7B, HDRP, KIAA0744, MITR |
Immunogen |
Recombinant full length Human HDAC 9. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.