ArtNr |
BS6435-50 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
BMP and activin membrane-bound inhibitor homolog, Non-metastatic gene A protein, Putative transmembrane protein NMA, BAMBI, NMA |
Similar products |
BAMBI |
Lieferbar |
|
Swiss-Prot |
Q13145 |
Application all |
WB: 1:500ca.1:2000 IHC: 1:50ca.1:200 |
Background |
BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA), also designated Non-metastatic gene A protein, is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development. The BAMBI family of proteins are related to type I TGF-beta receptor family, however, BAMBI is a pseudoreceptor that lacks an intracellular serine/threonine kinase domain. BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4. BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues. BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines. |
Product |
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
BAMBI polyclonal antibody detects endogenous levels of BAMBI protein. |
BiowMW |
ca. 29 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
BMP and activin membrane-bound inhibitor homolog, Non-metastatic gene A protein, Putative transmembrane protein NMA, BAMBI, NMA |
Immunogen |
Recombinant full length Human BAMBI. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.