CD3G polyclonal antibody

P09693

The T cell antigen receptor (TCR) recognizesforeign antigens and translates such recognition eventsinto intracellularsignalsthat elicit a change in the cell froma dormant to an activated state.Much of this signaling processcan be attributed to a multisubunitcomplex of proteins that associates directly with the TCR. Thiscomplex has been designated CD3 (cluster of differentiation 3). It iscomposed of five invariant polypeptide chainsthat associate to form three dimers: a heterodimer of gamma and epsilon chains(gammaepsilon), a heterodimer of delta and epsilon chains(deltaepsilon) and a homodimer of two zeta chains(zetazeta) or a heterodimer of zeta and eta chains(zetaeta). The zeta and eta chains are encoded bythe same gene but differ in theircarboxyl-terminal ends due to an alternative splicing event. The gamma, epsilon and delta chains each contain a single copy of a conserved immunoreceptor tyrosine-based activationmotif (ITAM). In contrast, the zeta chain containsthree consecutive copies of the same motif. Phosphorylated ITAMs act as docking sitesfor protein kinases such as ZAP-70 and Syk and are also capable of regulating theirkinase activity. The crystalstructure of ZAP-70's SH2 domains bound to the zeta chain ITAMs has been solved.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

CD3G pAb detects endogenous levels of CD3G protein.

ca. 20 kDa

T-cell surface glycoprotein CD3 gamma chain, T-cell receptor T3 gamma chain, CD3g, CD3G, T3G, CD3-gamma, CD3 gamma, CD3gamma