ArtNr |
BS60356-50 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
T-cell surface glycoprotein CD3 gamma chain, T-cell receptor T3 gamma chain, CD3g, CD3G, T3G, CD3-gamma, CD3 gamma, CD3gamma |
Similar products |
CD3G |
Lieferbar |
|
Swiss-Prot |
P09693 |
Application all |
WB: 1:500ca.1:1000 |
Background |
The T cell antigen receptor (TCR) recognizesforeign antigens and translates such recognition eventsinto intracellularsignalsthat elicit a change in the cell froma dormant to an activated state.Much of this signaling processcan be attributed to a multisubunitcomplex of proteins that associates directly with the TCR. Thiscomplex has been designated CD3 (cluster of differentiation 3). It iscomposed of five invariant polypeptide chainsthat associate to form three dimers: a heterodimer of gamma and epsilon chains(gammaepsilon), a heterodimer of delta and epsilon chains(deltaepsilon) and a homodimer of two zeta chains(zetazeta) or a heterodimer of zeta and eta chains(zetaeta). The zeta and eta chains are encoded bythe same gene but differ in theircarboxyl-terminal ends due to an alternative splicing event. The gamma, epsilon and delta chains each contain a single copy of a conserved immunoreceptor tyrosine-based activationmotif (ITAM). In contrast, the zeta chain containsthree consecutive copies of the same motif. Phosphorylated ITAMs act as docking sitesfor protein kinases such as ZAP-70 and Syk and are also capable of regulating theirkinase activity. The crystalstructure of ZAP-70's SH2 domains bound to the zeta chain ITAMs has been solved. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
CD3G pAb detects endogenous levels of CD3G protein. |
WB |
Western blot (WB) analysis of CD3G pAb at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:H9C2 whole cell lysate |
BiowMW |
ca. 20 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
T-cell surface glycoprotein CD3 gamma chain, T-cell receptor T3 gamma chain, CD3g, CD3G, T3G, CD3-gamma, CD3 gamma, CD3gamma |
Immunogen |
A synthetic peptide corresponding to residues in Human CD3G. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.