ArtNr |
BS60131-100 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Cation transport regulator-like protein 1, Blocks Notch protein, Botch, BOTCH |
Similar products |
CHAC1 |
Lieferbar |
|
Swiss-Prot |
Q9BUX1 |
Application all |
WB: 1:500ca.1:1000 |
Background |
CHAC1 (ChaC, cation transport regulator homolog 1 (E. coli)) is a 264 amino acid cytoplasmic protein that belongs to the ChaC family. Induced by chemical activators of the unfolded protein response (UPR) pathway, including DTT, tunicamycin and thapsigargin, CHAC1 is a pro-apoptotic member of this pathway and may mediate the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Overexpression of CHAC1 may lead to an increase in apoptosis, while suppression of CHAC1 results in subdued apoptosis. Existing as two alternatively spliced isoforms, the gene encoding CHAC1 maps to human chromosome 15q15.1. Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and comprises about 3% of the human genome. Angelman, Prader-Willi and Marfan syndromes are associated with loss of function or deletion of genes that are encoded by chromosome 15. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
CHAC1 pAb detects endogenous levels of CHAC1 protein. |
WB |
Western blot (WB) analysis of CHAC1 pAb at 1:500 dilution Lane1:Hela whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate |
BiowMW |
ca. 24-28 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
Cation transport regulator-like protein 1, Blocks Notch protein, Botch, BOTCH |
Immunogen |
A synthetic peptide corresponding to residues in Human CHAC1. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.