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PRPF18 polyclonal antibody

PRPF18 polyclonal antibody

Hersteller	Bioworld Technology, Inc
Kategorie	Metabolism Diabetes Antibodies Western Blot Immunocytochemistry Primary Antibodies
Typ	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Applikationen	WB, ICC
Menge	50ul
Host	Rabbit
ArtNr	BS5866-50
eClass 6.1	32160702
eClass 9.0	32160702
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Alias	Pre-mRNA-splicing factor 18, PRP18 homolog, hPRP18, PRP18, HPRP18
Swiss-Prot	Q99633
Application all	WB: 1:500ca.1:1000 ICC: 1:50ca.1:200
Background	PRPF18 (pre-mRNA-splicing factor 18), also known as HPRP18, is a 342 amino acid protein that localizes to nuclear speckles and plays a role in the second step of pre-mRNA splicing. A member of the PRP18 family, PRPF18 contains seven WD repeats and exists as two alternatively spliced isoforms which are encoded by a gene located on human chromosome 10p13. Chromosome 10 contains over 800 genes and 135 million nucleotides. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Other chromosome 10 associated disorders include Cockayne syndrome, tetrahydrobiopterin deficiency and trisomy 10.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	PRPF18 pAb detects endogenous levels of PRPF18 protein.
WB	Western blot (WB) analysis of PRPF18 pAb at 1:500 dilution Lane1:HEK29T cell lysate Lane2:sp2/0 cell lysate Lane3:H9C2 cell lysate
BiowMW	ca. 40 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Pre-mRNA-splicing factor 18, PRP18 homolog, hPRP18, PRP18, HPRP18
Immunogen	Synthetic peptide, corresponding to amino acids 223-268 of Human PRPF18.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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