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APP/β-Amyloid (phospho-T668) polyclonal antibody

APP/β-Amyloid (phospho-T668) polyclonal antibody

ArtNr	BS4214-100
Hersteller	Bioworld Technology, Inc
Menge	100 ul
Quantity options	100 ul 50 ul
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Adenocarcinoma Immunohistochemistry Western Blot Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody Polyclonal
Applikationen	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Konjugat/Tag	Unconjugated
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Amyloid beta A4 protein, ABPP, APPI, Short name=APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, Short name=CVAP, PreA4, Protease nexin-II, Short name=PN-II, N-APP, Soluble APP-alpha, Short name=S-APP-alpha, Soluble APP-beta, Short name=S-APP-beta, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, P3(42), P3(40), Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, Short name=AICD-59, Short name=AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, Short name=AICD-57, Short name=AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), APP, A4, AD, Amyloid-β, Amyloid β, Amyloidβ, β Amyloid, βAmyloid, Aβ
Similar products	APP/beta-Amyloid
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Application Notes	WB: 1:500~1:1000 IHC: 1:50~1:200
Background	Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the β-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer’s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the Amyloid β/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer’s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP.
Manufacturer - Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Manufacturer - Specificity	p-APP/β-Amyloid (T668) polyclonal antibody detects endogenous levels of APP695 protein only when phosphorylated at Thr668 (or the corresponding position on other isoforms).
Molecular Weight	~ 70 to140 kDa
Note	For research use only, not for use in diagnostic procedure.
Pathway	Neuronal and Glial Cell Marker Atlas, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease
Immunogen	Synthetic phosphopeptide derived from human APP/β-Amyloid around the phosphorylation site of Threonine 668.
Modification	Phosphorylation

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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