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p70 S6K (F438) polyclonal antibody

ArtNr BS3634-100
Hersteller Bioworld Technology, Inc
Menge 100 ul
Quantity options 100 ul 50 ul
Kategorie
Typ Antibody Polyclonal
Applikationen WB, IHC
Specific against Human, Mouse, Rat
Host Rabbit
Konjugat/Tag Unconjugated
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Ribosomal protein S6 kinase I, S6K, S6K1, 70 kDa ribosomal protein S6 kinase 1, p70 S6 kinase alpha, p70 S6K, p70-S6K, P70S6K, p70 S6 kinase α, Name: RPS6KB1, STK14A, p80 S6K1, p85 S6 kinase, p85 S6K, p85S6K
Similar products p70 S6K
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Application Notes
WB: 1:500~1:1000
IHC: 1:50~1:200
Background
p70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression. p70 S6 kinase phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. A second isoform, p85 S6 kinase, is derived from the same gene and is identical to p70 S6 kinase except for 23 extra residues at the amino terminus, which encode a nuclear localizing signal. Both isoforms lie on a mitogen activated signaling pathway downstream of phosphoinositide-3 kinase (PI-3K) and the target of rapamycin, FRAP/mTOR, a pathway distinct from the Ras/MAP kinase cascade. The activity of p70 S6 kinase is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains.
Manufacturer - Product
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Manufacturer - Specificity
p70 S6K (F438) polyclonal antibody detects endogenous levels of p70 S6 Kinase protein.This antibody also recognizes p85 S6 kinase protein.
Molecular Weight
~ 59, 70, 85 kDa
Note
For research use only, not for use in diagnostic procedure.
Pathway
PI3K AKT signaling, Protein Kinase C Signaling, Hypoxia Signaling, Translational Contral elF4 and p70 S6 Kinase, Inhibition of Apoptosis, Insulin &Glucose Signaling, MAPK Erk in Growth and Differentiation Pathway, Mitochondrial Control of Apoptosis, MTOR signaling, ErbB HER Signaling
Immunogen
Synthetic peptide, corresponding to amino acids 404-454 of Human p70 S6K.
Modification
Unmodification

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ul
Lieferbar: In stock
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