ArtNr |
BS3575-100 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Forkhead box protein O4, Fork head domain transcription factor AFX1, AFX, AFX1, MLLT7, FOXO4 |
Similar products |
FoxO4 |
Lieferbar |
|
Swiss-Prot |
P98177 |
Application all |
WB: 1:500ca.1:1000 IHC: 1:50ca.1:200 |
Background |
FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
FoxO4 (P191) pAb detects endogenous levels of FoxO4 protein. |
WB |
Western blot (WB) analysis of FoxO4 (P191) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:sp2/0 whole cell lysate Lane3:PC12 whole cell lysate |
IHC |
Immunohistochemistry (IHC) analyzes of FoxO4 (P191) pAb in paraffin-embedded human breast carcinoma tissue at 1:100. |
BiowMW |
ca. 55, 70 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
Forkhead box protein O4, Fork head domain transcription factor AFX1, AFX, AFX1, MLLT7, FOXO4 |
Immunogen |
Synthetic peptide, corresponding to amino acids 172-215 of Human FoxO4. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.