Hersteller |
Bioworld Technology, Inc
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human, Mouse, Rat |
Applikationen |
WB, IF, IHC |
Menge |
50ul |
Host |
Rabbit |
ArtNr |
BS2994-50 |
Targets |
SDC1;;SDC4 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Alias |
SDC4, AMPHIGLYCAN, MGC22217, SYND4 |
Swiss-Prot |
P31431 |
Application all |
WB: 1:500ca.1:1000 IHC: 1:50ca.1:200 IF: 1:50ca.1:200 |
Background |
Syndecans are type I integral membrane proteoglycans that contain both chondroitin sulfate and heparan sulfate groups. Syndecans are involved in cell-extracellular matrix adhesion and growth factor binding. Syndecan-1 (SYND1, also called CD138) is an 85-92 kDa extracellular matrix receptor, which binds to Collagens, Fibronectin and Thrombospondin. Syndecan-1 and Syndecan-3 (also designated N-Syndecan) interact with MK (midkine), a growth/differentiation factor invloved in embryogenesis of the central nervous system. Syndecan-2 (also designated Fibroglycan) is highly expressed at areas of high morphogenetic activity, such as epithelial-mesenchymal interfaces and the prechondrogenic and preosteogenic mesenchymal condensations. Syndecan-4 (also designated Amphiglycan or Ryudocan) functions cooperatively with integrins in the processes of cell spreading, focal adhesion assembly and actin stress fiber assembly. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
Syndecan-4 (K175) pAb detects endogenous levels of Syndecan-4 protein. |
IHC |
Immunohistochemistry (IHC) analyzes of Syndecan-4 (K175) pAb in paraffin-embedded human brain tissue . |
BiowMW |
ca. 22 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
SDC4, AMPHIGLYCAN, MGC22217, SYND4 |
Immunogen |
Synthetic peptide, corresponding to amino acids 150-198 of Human Syndecan-4. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.