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Glucagon Receptor (K136) polyclonal antibody

Glucagon Receptor (K136) polyclonal antibody

ArtNr	BS2718-100
Hersteller	Bioworld Technology, Inc
Menge	100ul
Kategorie	Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Antibodies Western Blot Immunofluorescence Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, IF
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Glucagon receptor, GL-R, GCGR
Similar products	Glucagon Receptor
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Swiss-Prot	P47871
Application all	WB: 1:500ca.1:1000 IF: 1:50ca.1:200
Background	Glucagon, a pancreatic hormone, functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior. Both glucagon and GLP-1 function through their specific binding to the glucagon receptor or GLP-1R, respectively. The glucagon receptor shows expression in liver, kidney and adipose tissue. The 56 GLP-1R expression primarily localizes to areas of the hypothalamus involved in feeding behavior. Both receptors and their ligands serve as potential targets for the therapeutic treatment of diabetes.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	Glucagon Receptor (K136) pAb detects endogenous levels of Glucagon Receptor protein.
WB	Western blot (WB) analysis of Glucagon Receptor (K136) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:H9C2 whole cell lysate
BiowMW	ca. 54 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Glucagon receptor, GL-R, GCGR
Immunogen	Synthetic peptide, corresponding to amino acids 100-150 of Human Glucagon Receptor.

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