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TSC22 (E73) polyclonal antibody

TSC22 (E73) polyclonal antibody

ArtNr	BS2661-50
Hersteller	Bioworld Technology, Inc
Menge	50ul
Kategorie	Neuroscience Neuroinflammation Antibodies Cell Biology Cell Culture Cytokines Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, IF, IHC
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	TSC22 domain family protein 1, Cerebral protein 2, Regulatory protein TSC-22, TGFB-stimulated clone 22 homolog, Transforming growth factor beta-1-induced transcript 4 protein, TSC22D1, KIAA1994, TGFB1I4, TSC22, hucep-2
Similar products	TSC22
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Swiss-Prot	Q15714
Application all	WB: 1:500ca.1:1000 IHC: 1:50ca.1:200 IF: 1:50ca.1:200
Background	Transforming growth factor-beta-stimulated clone-22 (TSC-22) acts as a transcriptionalregulator to modulate cell growth and differentiation and cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in the TGF-beta pathway, and also the PPARgamma signalling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, such as brain and salivary gland tumors, imply an antiproliferative role for TSC-22.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	TSC-22 (E73) pAb detects endogenous levels of TSC-22 protein.
WB	Western blot (WB) analysis of TSC22 (E73) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate
IHC	Immunohistochemistry (IHC) analyzes of TSC-22 (E73) pAb in paraffin-embedded human brain tissue.
BiowMW	ca. 16 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	TSC22 domain family protein 1, Cerebral protein 2, Regulatory protein TSC-22, TGFB-stimulated clone 22 homolog, Transforming growth factor beta-1-induced transcript 4 protein, TSC22D1, KIAA1994, TGFB1I4, TSC22, hucep-2
Immunogen	Synthetic peptide, corresponding to amino acids 41-93 of Human TSC22.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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