ArtNr |
BS2299-50 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
ELAV like 4, ELAV like neuronal protein 1, ELAV like protein 2, ELAV like protein 4, ELAVL 2, ELAVL 4, HELN1, Hu antigen B, Hu antigen D, HUB, HUD, Hel-N1, ELAVL2, HEL-N1, HELN1, HUB |
Similar products |
Hel-N1 |
Lieferbar |
|
Swiss-Prot |
Q12926 |
Application all |
WB: 1:500ca.1:1000 |
Background |
The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs (RRM), and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
Hel-N1 (S27) pAb detects endogenous levels of HuB protein. |
WB |
Western blot (WB) analysis of Hel-N1 (S27) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate |
BiowMW |
ca. 38 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
ELAV like 4, ELAV like neuronal protein 1, ELAV like protein 2, ELAV like protein 4, ELAVL 2, ELAVL 4, HELN1, Hu antigen B, Hu antigen D, HUB, HUD, Hel-N1, ELAVL2, HEL-N1, HELN1, HUB |
Immunogen |
Synthetic peptide, corresponding to the N-terminus of Human Hel-N1. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.