Hel-N1 (S27) polyclonal antibody

Q12926

The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs (RRM), and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Hel-N1 (S27) pAb detects endogenous levels of HuB protein.

ca. 38 kDa

ELAV like 4, ELAV like neuronal protein 1, ELAV like protein 2, ELAV like protein 4, ELAVL 2, ELAVL 4, HELN1, Hu antigen B, Hu antigen D, HUB, HUD, Hel-N1, ELAVL2, HEL-N1, HELN1, HUB