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TDG (K90) polyclonal antibody

ArtNr BS2053-100
Hersteller Bioworld Technology, Inc
Menge 100 ul
Quantity options 100 ul 50 ul
Kategorie
Typ Antibody Polyclonal
Applikationen WB, IF, IHC
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Konjugat/Tag Unconjugated
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias G/T mismatch-specific thymine DNA glycosylase, Thymine-DNA glycosylase, Short name=hTDG, Thymine DNA glycosylase, hTDG
Similar products TDG
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Application Notes
WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200
Background
In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. G/T mismatch-specific Thymine DNA Glycosylase (TDG) is a nuclear protein which corrects G/T mismatches to G/C pairs by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired thymine. TDG also corrects a subset of G/U mispairs inefficiently removed by the more abundant uracil glycosylases. Retinoic acid receptors interact physically and functionally with TDG, enhancing the ability of the retinoid X receptor and the retinoid X receptor/retinoid acid receptor complex to bind to their response elements. TDG interacts with, and is covalently modified by, the ubiquitin-like proteins SUMO-1 and SUMO-2/3, resulting in a reduction of the DNA substrate and AP site binding affinity of TDG. This sumoylation is associated with a significant increase in enzymatic turnover in reactions with a G/U substrate and the loss of G/T processing activity.
Manufacturer - Product
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Manufacturer - Specificity
TDG (K90) polyclonal antibody detects endogenous levels of TDG protein.
Molecular Weight
~ 46 kDa
Note
For research use only, not for use in diagnostic procedure.
Immunogen
Synthetic peptide, corresponding to amino acids 28-109 of Human TDG.
Modification
Unmodification

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ul
Lieferbar: In stock
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