ArtNr |
BS1716-50 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IF, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR, Beta-2 adrenergic receptor, ARbeta2 |
Similar products |
AR-beta2 |
Lieferbar |
|
Swiss-Prot |
P07550 |
Application all |
WB: 1:500ca.1:1000 IHC: 1:50ca.1:200 IF: 1:50ca.1:200 |
Background |
Beta 2 Adrenergic Receptor is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. Expression of the beta 2 Adrenergic Receptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
AR-beta2 (L342) pAb detects endogenous levels of AR-beta2 protein. |
WB |
Western blot (WB) analysis of AR-beta2 (L342) pAb at 1:500 dilution Lane1:HepG2 cell lysate Lane2:Mouse kidney tissue lysate Lane3:Rat kidney tissue lysate |
IHC |
Immunohistochemistry (IHC) analyzes of AR-beta2 (L342) pAb in paraffin-embedded human breast carcinoma tissue at 1:50. |
BiowMW |
ca. 47 kDa, 68 kDa (glycosylated), 95 kDa (Dimer) |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR, Beta-2 adrenergic receptor, ARbeta2 |
Immunogen |
Synthetic peptide, corresponding to amino acids 311-360 of Human AR-beta2. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.