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Ku-70 (R586) polyclonal antibody

Ku-70 (R586) polyclonal antibody

ArtNr	BS1498-50
Hersteller	Bioworld Technology, Inc
Menge	50ul
Kategorie	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, IHC
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	X-ray repair cross-complementing protein 6, 5'-deoxyribose-5-phosphate lyase Ku70, 5'-dRP lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, CTC box-binding factor 75 kDa subunit
Similar products	Ku-70
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Swiss-Prot	P12956
Application all	WB: 1:500ca.1:1000 IHC: 1:50ca.1:200
Background	The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 (or p86), which is also known by the synonym Ku-80 (or p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma-polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	Ku-70 (R586) pAb detects endogenous levels of Ku-70 protein
WB	Western blot (WB) analysis of Ku-70 (R586) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate
IHC	Immunohistochemistry (IHC) analyzes of Ku-70 (R586) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
BiowMW	ca. 70 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	X-ray repair cross-complementing protein 6, 5'-deoxyribose-5-phosphate lyase Ku70, 5'-dRP lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, CTC box-binding factor 75 kDa subunit, CTC75, CTCBF, DNA repair protein XRCC6, Lupus Ku autoantigen protein p70, Ku70, Thyroid-lupus autoantigen, TLAA, X-ray repair complementing defective repair in, Chinese hamster cells 6, XRCC6, G22P1
Immunogen	Synthetic peptide, corresponding to amino acids 560-600 of Human Ku-70.

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