TH (G13) polyclonal antibody

P07101

The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson's disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Tyrosine Hydroxylase (G13) pAb detects endogenous levels of Tyrosine Hydroxylase protein.

Immunohistochemistry (IHC) analyzes of TH (G13) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

For research use only, not for use in diagnostic procedure.

Synthetic peptide, corresponding to the N-terminus of Human TH.