ArtNr |
BS1163-50 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IF, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Histone deacetylase 5, Short name=HD5, Antigen NY-CO-9, HDAC-5, KIAA0600 |
Similar products |
HDAC5 |
Lieferbar |
|
Swiss-Prot |
Q9UQL6 |
Application all |
WB: 1:500ca.1:1000 IHC: 1:50ca.1:200 IF: 1:50ca.1:200 |
Background |
HDAC5 is a member of the class II mammalian histone deacetylase family, which is structurally related to yeast HDA1. Human HDAC5 is composed of 1122 amino acid residues. The deacetylase domain of HDAC5 is located at the C-terminal half of the molecule. The N-terminal non-deacetylase domain does not show any significant homology with any published sequence.Both domains are required for HDAC5-mediated repression of gene transcription. HDAC5 interacts with a growing number of transcriptional factors including MEF2A as well as other HDAC proteins. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
HDAC5 (E1106) pAb detects endogenous levels of HDAC5 protein. |
WB |
Western blot (WB) analysis of HDAC5 (E1106) pAb at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:Mouse liver tissue lysate Lane3:Rat liver tissue lysate |
IHC |
Immunohistochemistry (IHC) analyzes of HDAC5 (E1106) pAb in paraffin-embedded human breast carcinoma tissue at 1:100. |
BiowMW |
ca. 121 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
Histone deacetylase 5, Short name=HD5, Antigen NY-CO-9, HDAC-5, KIAA0600 |
Immunogen |
Synthetic peptide, corresponding to the C-terminus of Human HDAC5. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.